The Effect Of Close Contact History And Housing Density On The Incidence Of Tuberculosis In The Lembeyan Health Center Area, Magetan Regency

Fadilah Nurul Ayu Lestari, Retno Widiarini, Zaenal Abidin — Sat, 04 Oct 2025 00:00:00 +0000

Based on a report from the Magetan Regency Health Office in 2021-2023, tuberculosis (TB) cases increased by 309 cases. In the working area of the Lembeyan Health Center, the number of TB cases increased to 33 cases in 2023–2024. This suggests that TB is still a health problem that needs attention. This study aims to analyze the effect of close contact history and residential density on TB incidence. The type of research used is observational analytics with a case control design. The research sample amounted to 34 respondents consisting of 17 cases and 17 controls, selected using the purposive sampling method. Data was collected through questionnaires and observation sheets. Data analysis was carried out univariately, bivariate with chi-square test. The results showed that there was a significant influence between the history of close contact (p=0.002) and residential density (p=0.016) with the incidence of TB. The conclusion of this study is that there is a significant influence between the history of close contact and residential density with the incidence of TB. Therefore, TB prevention needs to be focused on improving residential environmental conditions, education of at-risk groups, and monitoring of individuals with a history of close contact with TB patients.

The Effect Of Ethanolic Extract Of Katuk Leaf (Sauropus Androgynus) On Malondialdehyde (MDA) Levels In Ovalbumin-Induced Atopic Dermatitis Model Mice

Hikmah Shabrina Dinda Izzaty, Winawati Eka Putri, Shobihatus Syifak — Sat, 04 Oct 2025 00:00:00 +0000

Background: Consensus guidelines have been developed to provide current and concise evidence-based recommendations directed to general practitioners and dermatologists in the Asia-Pacific region regarding the management of pediatric and adult AD. In previous studies there were differences regarding MDA levels in AD and non-AD patients. This can be an indication of oral antioxidants to reduce MDA levels in AD patients. Antioxidants themselves are contained in many traditional medicinal plants that are often found in Indonesia, including katuk leaves. Objective: To analyze the effect of the ethanol extract of katuk leaves (Sauropus androgynus) on MDA levels in mice model of atopic dermatitis induced by ovalbumin. Methods: This study used an experimental method using mice with a total sample of 36 individuals. The dosages of katuk leaf extract used were 100 mg/Kg, 200 mg/Kg, and 400 mg/Kg, the parameters measured were plasma MDA and skin tissue using the Wills method. The results obtained will be processed using the One Way ANOVA test and the Kruskal Wallis test. Results: The results of this study were the value of plasma MDA levels in the DA model mice had higher levels than non-DA with a value of 570.5 nmol / L as well as tissue MDA levels with a value of 1727 nmol / g. However, based on the results of different tests between groups with both plasma and tissue MDA variables, both of them had a p value> 0.05, which means they did not have a significant difference between groups. Conclusion: In this study, the results were not significant in giving ethanol extract of katuk leaves on plasma and tissue MDA levels in DA model mice.

Asian Journal of Healthy and Science

The Effect Of Close Contact History And Housing Density On The Incidence Of Tuberculosis In The Lembeyan Health Center Area, Magetan Regency

The Effect Of Ethanolic Extract Of Katuk Leaf (Sauropus Androgynus) On Malondialdehyde (MDA) Levels In Ovalbumin-Induced Atopic Dermatitis Model Mice