https://ajhsjournal.ph/index.php/gp/issue/feed 2026-01-12T03:05:00+00:00 AJHS Official support@ajhsjournal.ph Open Journal Systems <p><strong>Asian Journal of Healthy and Science</strong> Journal E-ISSN <a href="https://portal.issn.org/resource/ISSN/2980-4310">2980-4310</a> | P-ISSN <a href="https://portal.issn.org/resource/ISSN/2980-4302">2980-4302</a> is a peer-reviewed open access scientific journal published by Central Publishing. The scope for <strong>Asian Journal of Healthy and Science </strong>Journal consist of all aspect of midwifery discipline, clinical and interprofessional topics including perinatal care, maternal and neonatal care, all aspect of obstetric discipline, gynaecology, gastroenterology, sexual and reproductive health, management midwifery care services, primary care, public health, health care policy, and global health. Articles published in <strong>Asian Journal of Healthy and Science</strong> Journal include <em>original articles </em>and <em>literature reviews</em>. Articles could be written in English. Contributors for <strong>Asian Journal of Healthy and Science</strong> Journal are researchers, lecturers, students, midwifery practitioners and other practitioners that focus on midwifery and health sciences worldwide.</p> <p> </p> https://ajhsjournal.ph/index.php/gp/article/view/276 2025-12-27T08:01:55+00:00 Muhamad Firmansyah Idrus faridaspp@uwks.ac.id Johanes Aprilius Falerio Kristijanto faridaspp@uwks.ac.id Muzaijadah Retno Arimbi faridaspp@uwks.ac.id Mira Kusuma Wardhani faridaspp@uwks.ac.id Rini Purbowati faridaspp@uwks.ac.id Naufal Syafawi SP faridaspp@uwks.ac.id Farida Anggraini Soetedjo faridaspp@uwks.ac.id

<p>Cigarette smoking is a recognized risk factor for chronic kidney disease, and experimental data suggest that renal damage may persist even after smoking cessation. <em>Peperomia pellucida</em>, a traditional medicinal plant, has documented antioxidant and anti-inflammatory activities and is used empirically for kidney disorders, but its role in reversing smoke-related renal injury is unclear. This study aimed to evaluate whether total <em>P. pellucida</em> extract can reverse established renal structural damage following cessation of cigarette smoke exposure in a Wistar rat model. Eighteen healthy male Wistar rats (8–12 weeks, 180–220 g) were randomly assigned to control (CON), cigarette smoke–exposed (CSE), and cigarette smoke–exposed plus <em>P. pellucida</em> (CSE+PP400) groups (n=6 each). CSE and CSE+PP400 animals were exposed to cigarette smoke in a whole-body chamber (two cigarettes/rat/day, 4 h/day, 7 days/week) for 4 weeks. Smoke exposure was then discontinued for 4 weeks. During this post-cessation period, CSE+PP400 rats received total <em>P. pellucida</em> extract 400 mg/kg/day orally; CON and CSE received vehicle only. At study end, kidneys were processed for hematoxylin–eosin staining and scored using the EGTI (Endothelial, Glomerular, Tubular, Interstitial) system by two blinded pathologists. Data were analyzed using two-way ANOVA. CSE rats showed marked renal injury, with significantly higher EGTI scores in all compartments versus CON. Post-cessation <em>P. pellucida</em> treatment significantly reduced endothelial, glomerular, tubular, and interstitial scores compared with untreated CSE rats, although values remained above control levels. No treatment-related mortality was observed. In conclusion, total <em>P. pellucida</em> extract administered after smoking cessation partially reverses cigarette smoke–induced renal structural damage in Wistar rats, supporting its potential as an adjunctive nephroprotective option in cigarette smoke-related kidney injury.</p>

2026-01-12T00:00:00+00:00 Copyright (c) 2026 Farida Anggraini Soetedjo, Muhamad Firmansyah Idrus, Johanes Aprilius Falerio Kristijanto, Muzaijadah Retno Arimbi, Mira Kusuma Wardhani, Rini Purbowati, Naufal Syafawi SP